Loading...
RESEARCH 2017-08-07T20:29:39+00:00

Starting Fall/Winter 2017

2017

“A prospective Multicenter Randomized and Controlled Study Comparing Laser and Mist Therapies for Treatment of Moderate to Severe Generalized Periodontitis”

Sponsor: BioLase and The McGuire Institute

Principal Investigator: Michael K. McGuire, D.D.S.

Co-Investigator: E. Todd Scheyer, D.D.S., M.S.

Currently Enrolling

2016 – Present

“A pharmacokinetic Pilot followed by a Phase I/II, Blinded, Randomized, Controlled, Parallel Arm Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® and Scaling and Root Planing in Subjects with Periodontitis”.

Sponsor: Giestlich

Principal Investigator: Michael K. McGuire, D.D.S.

Co-Investigator: E. Todd Scheyer, D.D.S, M.S.

2016-2017

“A prospective, randomized, controlled, multi-center evaluation of extraction socket management comparing CollaPlug® and Mucograft Seal®”

Sponsor: Geistlich Pharma NA

Principal Investigator: Michael K. McGuire, D.D.S. and E. Todd Scheyer, D.D.S., M.S.

2016

“Long-term Clinical Evaluation of Dental Implants”.

Sponsor:  The McGuire Institute

Principal Investigator: Michael K. McGuire, D.D.S. and E. Todd Scheyer, D.D.S., M.S.

2015-2016

“A pharmacokinetic Pilot followed by a Phase I/II, Blinded, Randomized, Controlled, Parallel Arm Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® and Scaling and Root Planing in Subjects with Periodontitis.”

Sponsor: Giestlich

Principal Investigator: Michael K. McGuire, D.D.S.

Co-Investigator: E. Todd Scheyer, D.D.S, M.S.

2012-2014

“Evaluation of Human Ginigival Recesion Defects Treated with Coronally Advanced Flaps and Either β-TCP + rhPDGF-BB (GEM 21S®) or Connective Tissue: Comparison of Clinical Parameters at 5 or More Years Floowing Completion of Protocol 1GEM04001”

Sponsor: Luitpold

Principal Investigator: Michael K. McGuire, D.D.S.

Co-Investigator: E. Todd Scheyer

2011-Present

“Clinical Analysis of a Biomimetric Implant System: Five Year survival rates, Marginal Bone-Level Changes, and Soft tissue Aesthetics”

Sponsor: Keystone Dental

Principal Investigator E. Todd Scheyer, D.D.D, M.S.

Co-Investigator Michael k. McGuire, D.D.S.

2011-2016

“A Prospective, Case-Controlled Study Evaluating the Use of Straumann Emdogain with Coronally Advanced Flap Versus Connective Tissue Graft with Coronally Advanced Flap on Human Buccal Recession Defects; A Human Histology Study”

Sponsor: Straumann

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E.Todd Scheyer, D.D.S., M.S.

2010-Present 

“A Clinical Trial to Evaluate Mucograft® Collagen Matrix as an Alternative to Free Gingival Grafting for Oral Soft Tissue Augmentation”

Sponsor: Geistlich Pharma AG

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E.Todd Scheyer, D.D.S., M.S.

2008-Present 

“Prospective Comparative Assessment of Single-Tooth Replacement in Different Implant-Abutment Interface Settings”

Sponsor: Astra Tech

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator, E. Todd Scheyer, D.D.S., M.S.

2009-2011

“An Open label, Non-Randomized, Single-Arm, Multi-Center Study to Assess Sinus Augmentation (Sinus Lift) Utilizing INFUSE® Bone Graft Concurrent with Dental Implant Placement”

Sponsor: Medtronic

Principal Investigator Michael K. McGuire, D.D.S. and E.Todd Scheyer, D.D.S., M.S.

2009-2010

“A Post-Market Clinical, Radiographic and Histologic Evaluation of DynBlast ™ DBM Putty and Paste in Extraction Socket Procedures”

Sponsor: Keystone

Principal Investigator E. Todd Scheyer, D.D.S., M.S.

Co-Investigator Michael K. McGuire, D.D.S.

2007-2010

“A Prospective, Randomized, Controlled Pilot Study of CelTx™ (Apligraf®)* as an Alternative to Tissue from the Palate in the Treatment of Gingival Recession Requiring Root Coverage”

Sponsor: Organogenesis

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E. Todd Scheyer, D.D.S., M.S.

2009

“Clinical Evaluation of GEM 21S® Containing a narrower Particle Range of β-Tricalcium Phosphate in Human Periodontal osseous Defects”

Sponsor: Luitpold

Principal Investigator Michael K. McGuire, D.D.S. and E.Todd Scheyer, D.D.S., M.S.

2007-2009

“A Clinical Trial to Evaluate CelTx™ (Apligraf®) as an Alternative to Tissue From the Palate to Enhance Oral Soft Tissue Regeneration and Wound Healing”

Sponsor: Organogenesis

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E. Todd Scheyer, D.D.S, M.S.

2007-2008

“A Clinical Trial to Evaluate CelTx™ (Apligraf®) as an Alternative to Tissue From the Palate to Enhance Oral Soft Tissue Regeneration and Wound Healing”

Sponsor: Organogenesis

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E. Todd Scheyer, D.D.S, M.S.

2007-2009

“A Prospective randomized Controlled Study of Bio-Guide, Ossix™, and Ossix Plus™ Membranes used in Guided Bone Regeneration of Dehiscence and Fenestration Cases”

Sponsor: Perio Health Clinical Research Center

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E. Todd Scheyer, D.D.S., M.S.

2006-2008

“A Single- Blind, Controlled, Split-Mouth, Single-Center Clinical Trial to Evaluate the Safety and Effectiveness of Mucograft™ compared to Subepithelial Connective Tissue Graft (CTG) for the Treatment of Dehiscence-Type Recession Periodontal Defects “

Sponsor: Geistlich Pharma G

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E. Todd Scheyer, D.D.S., M.S.

2005-2008

“A Phase II Open-Label Study to Determine the Saftey and Efficacy of Isolagen™ Therapy for Treatment of Interdental Papillary Insufficiency.”

Sponsor: Isolagen

Principal Investigator Michael K. McGuire D.D.S.

Co-Investigator E.Todd Scheyer, D.D.S., M.S.

2005-2007

“A Single-Blind, Controlled, Split Mouth, Single- Center Study to Evaluate Saftey and Effectiveness of GEM 21S Associated with GTR Membrane Compared to Sub-epithelial Connective Tissue Graft (CTG) for Treatment of Recession-Type Periodontal Defects”

Sponsor: Osteohealth/Luitpold

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E. Todd Scheyer, D.D.S., M.S.

2004-2006

“A Prospective, Randomized-Controlled Study of Ossixä and Bio-Guideâ Membranes used in Guided Bone Regeneration of Dehiscence and Fenestration Cases.”

Sponsor: 3i Implant Innovations

Principal Investigator Michael K. McGuire, D.D.S.

Co-Investigator E. Todd Scheyer, D.D.S., M.S.

2005-2006

“A Pilot Clinical Trial to Assess the Safety and Efficacy of Apligraf® in Establishing a Functional Zone of Attached Gingiva”

Sponsor: Organogenesis

Principal Investigator Michael K. McGuire D.D.S.
Co-Investigator E.Todd Scheyer, D.D.S., M.S.

2004-2006

“A Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety and Efficacy of Isolagen Injections for Treatment of Interdentally Papillary Insufficiency”

Sponsor: Isolagen

Principal Investigator Michael K. McGuire D.D.S.

Co-Investigator E.Todd Scheyer, D.D.S., M.S.

2003-2004

“A Blinded-Human clinical Trial to Evaluate the Clinical Utility of GEM 21S for the Treatment of General Bone Defects”

Sponsor: Biomimetic Pharmaceuticals

Principal Investigator Michael K. McGuire D.D.S.

Co-Investigator E.Todd Scheyer, D.D.S., M.S.

2002-2003

“A Randomized Double-Blind, Controlled, Parallel-Arm, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of B-TCP Plus for the Treatment of Periodontal Bone Defects”

Sponsor: Biomimetic Pharmaceuticals

Principal Investigator Michael K. McGuire D.D.S.

Co-Investigator E.Todd Scheyer, D.D.S., M.S.

2000-2002

“Free Autogenous Graft Pilot Study Utilizing Human Dermal Fibroblasts”

Sponsor: Advanced Tissue Sciences

Principal Investigator Michael K. McGuire D.D.S.

2000-2001

“A Pilot Study of the Clinical applicability of the Minocycline Periodontal Therapeutics System When Used Adjunctively with Scaling and Root Planing for the Treatment of Non-Responding Periodontal Sites”

Sponsor: OraPharma

Principal Investigator Michael K. McGuire D.D.S.

1999-2001

“The Evaluation of Emdogain ® in Treatment of Recession Type Defects”

Sponsor: Biora

Principal Investigator Michael K. McGuire D.D.S.

1994-1995

“Host Factor Relationships in Periodontal Regenerative Therapy”

Sponsor: Proctor & Gamble

Principal Investigator Michael K. McGuire D.D.S.

1994

“A Six Month Multicenter Evaluation of Adjunctive Tetracycline Fiber therapy used in Conjunction with Scaling and Root Planing in Maintenance Patients”

Sponsor: Proctor & Gamble

Principal Investigator Michael K. McGuire D.D.S.

1993-1994

“Adjunctive use of Azithromycin in Treatment of Refractory Periodontitis”

Sponsor: Proctor & Gamble

Principal Investigator Michael K. McGuire D.D.S.

1990

“Clinical and Microbial Patterns of Adults with Periodontitis”

Sponsor: Michael K. McGuire, D.D.S.

Principal Investigator Michael K. McGuire D.D.S.

1989-1994

“Open-Label Study to Evaluate Treatment Use of PTS (Periodontal Therapeutic System) (Tetracycline)”

Sponsor: Proctor Gamble/Alza Corp

Principal Investigator Michael K. McGuire, D.D.S.

1989-1990

“A Multi-Center Study to Evaluate Scaling & Root Planing With and Without PTS

(Periodontal Therapeutic System) (Tetracycline) in Refractory Maintenance Patients”

Sponsor: Alza Corp

Principal Investigator Michael K. McGuire, D.D.S.